Genomic stability: boosting cohesion corrects CIN

Curr Biol. 2014 Jun 16;24(12):R571-R573. doi: 10.1016/j.cub.2014.05.009.

Abstract

Chromosomal instability is a driving force for heterogeneity within tumours. A recent study shows that boosting sister chromatid cohesion corrects chromosomal instability in pRB-deficient cancer cells. This key finding provides an important lead to make tumours more susceptible to anti-cancer drugs.

Publication types

  • Comment

MeSH terms

  • Cell Cycle Proteins / genetics*
  • Cell Transformation, Neoplastic / genetics*
  • Chromosomal Instability*
  • Chromosomal Proteins, Non-Histone / genetics*
  • Gene Expression Regulation, Neoplastic*
  • Histones / genetics*
  • Humans
  • Retinoblastoma Protein / genetics*

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • Histones
  • Retinoblastoma Protein