Abstract
Chromosomal instability is a driving force for heterogeneity within tumours. A recent study shows that boosting sister chromatid cohesion corrects chromosomal instability in pRB-deficient cancer cells. This key finding provides an important lead to make tumours more susceptible to anti-cancer drugs.
Copyright © 2014 Elsevier Ltd. All rights reserved.
MeSH terms
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Cell Cycle Proteins / genetics*
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Cell Transformation, Neoplastic / genetics*
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Chromosomal Instability*
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Chromosomal Proteins, Non-Histone / genetics*
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Gene Expression Regulation, Neoplastic*
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Histones / genetics*
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Humans
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Retinoblastoma Protein / genetics*
Substances
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Cell Cycle Proteins
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Chromosomal Proteins, Non-Histone
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Histones
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Retinoblastoma Protein