Pancreatic cancer stroma: friend or foe?

Cancer Cell. 2014 Jun 16;25(6):711-2. doi: 10.1016/j.ccr.2014.05.026.


Pancreatic cancer desmoplasia is thought to confer biological aggressiveness. In this issue of Cancer Cell, Özdemir and colleagues and Rhim and colleagues demonstrate that targeting the stroma results in undifferentiated, aggressive pancreatic cancer that responds to checkpoint blockade or antiangiogenic therapy, uncovering a protective role by stroma in this cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Carcinoma, Pancreatic Ductal / pathology*
  • Humans
  • Pancreatic Neoplasms / pathology*
  • Stromal Cells / pathology*