MDS Is a Stem Cell Disorder After All

Cancer Cell. 2014 Jun 16;25(6):713-4. doi: 10.1016/j.ccr.2014.06.001.

Abstract

Myelodysplastic syndrome (MDS) has long been presumed to be a stem cell disorder, but rigorous formal proof has been lacking. In this issue of Cancer Cell, Woll and colleagues demonstrate that driver mutations occurring in MDS definitively occur in cells with a stem cell phenotype.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Myelodysplastic Syndromes / genetics*
  • Myelodysplastic Syndromes / pathology*
  • Neoplastic Stem Cells / physiology*