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MRI Segmentation Analysis in Temporal Lobe and Idiopathic Generalized Epilepsy

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MRI Segmentation Analysis in Temporal Lobe and Idiopathic Generalized Epilepsy

Hila Goldberg et al. BMC Neurol.

Abstract

Background: Temporal lobe epilepsy (TLE) and idiopathic generalized epilepsy (IGE) patients have each been associated with extensive brain atrophy findings, yet to date there are no reports of head to head comparison of both patient groups. Our aim was to assess and compare between tissue-specific and structural brain atrophy findings in TLE to IGE patients and to healthy controls (HC).

Methods: TLE patients were classified in TLE lesional (L-TLE) or non-lesional (NL-TLE) based on presence or absence of MRI temporal structural abnormalities. High resolution 3 T MRI with automated segmentation by SIENAX and FIRST tools were performed in a group of patients with temporal lobe epilepsy (11 L-TLE and 15 NL-TLE) and in15 IGE as well as in 26 HC. Normal brain volume (NBV), normal grey matter volume (NGMV), normal white matter volume (NWMV), and volumes of subcortical deep grey matter structures were quantified. Using regression analyses, differences between the groups in both volume and left/right asymmetry were evaluated. Additionally, laterality of results was also evaluated to separately quantify ipsilateral and contralateral effects in the TLE group.

Results: All epilepsy groups had significantly lower NBV and NWMV compared to HC (p < 0.001). L-TLE had lower hippocampal volume than HC and IGE (p = 0.001), and all epilepsy groups had significantly lower amygdala volume than HC (p < = 0.004). In L-TLE, there was evidence of atrophy in both ipsilateral and contralateral structures.

Conclusions: Our study revealed that TLE and IGE patients demonstrated similar overall tissue-specific brain atrophy, although specific structures differences were appreciated. L-TLE also appeared to behave differently than NL-TLE, with atrophy not limited to the ipsilateral side.

Figures

Figure 1
Figure 1
An axial and coronal MRI slice demonstrating the FIRST segmentation of the subcortical deep GM structures.
Figure 2
Figure 2
Boxplots showing normalized brain parenchymal volume (NBV), normalized gray matter volume (NGMV), and normalized white matter volume (NWMV) in patients with IGE, NL-TLE, L-TLE, and healthy controls (HC). Volumes are in cm3.
Figure 3
Figure 3
Volumes of the amygdala, caudate, hippocampus, thalamus, pallidum and putamen in patients with IGE, L-TLE, NL-TLE, and in healthy controls (HC). Volumes are in cm3. Standard error bars are presented.
Figure 4
Figure 4
Left/right asymmetry in volumes of the amygdala, caudate, hippocampus, thalamus, pallidum and putamen in patients with IGE, L-TLE, NL-TLE, and in healthy controls (HC). Volumes are in cm3.
Figure 5
Figure 5
Ipsilaterl and contralateral volumes of the amygdala, caudate, hippocampus, thalamus, pallidum and putamen in patients L-TLE and in healthy controls (HC). Volumes are in cm3.

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References

    1. Engel J Jr. Introduction to temporal lobe epilepsy. Epilepsy Res. 1996;26:141–150. - PubMed
    1. Bonilha L, Halford JJ, Rorden C, Roberts DR, Rumboldt Z, Eckert MA. Automated MRI analysis for identification of hippocampal atrophy in temporal lobe epilepsy. Epilepsia. 2009;50:228–233. - PubMed
    1. Bonilha L, Kobayashi E, Rorden C, Cendes F, Li LM. Medial temporal lobe atrophy in patients with refractory temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2003;74:1627–1630. - PMC - PubMed
    1. Garcia-Finana M, Denby CE, Keller SS, Wieshmann UC, Roberst N. Degree of hippocampal atrophy is related to side of seizure onset in temporal lobe epilepsy. AJNR Am J Neuroradiol. 2006;27:1046–1052. - PubMed
    1. Hogan RE, Wang L, Bertrand ME, Willmore LJ, Bucholz RD, Nassif AS, Csernansky JG. MRI-based high-dimensional hippocampal mapping in mesial temporal lobe epilepsy. Brain. 2004;127:1731–1740. - PubMed

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