[New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy]

Med Sci (Paris). 2014 May;30(5):519-25. doi: 10.1051/medsci/20143005014. Epub 2014 Jun 13.
[Article in French]


PLA2R1 is a large transmembrane receptor of 180-kDa that belongs to the superfamily of C-type lectins. It was discovered because of its high affinity for secreted phospholipases A2 (sPLA2), enzymes that play a key role in lipid mediator synthesis. Early PLA2R1 physiological roles include the clearance of sPLA2 from the extracellular medium and/or promotion of their actions. Over the last four years, two independent studies suggested that PLA2R1 plays a role in cancer as a tumor gene suppressor and is the major target antigen of auto-immune antibodies involved in idiopathic membranous nephropathy, a severe human kidney disease. These novel findings shed light on PLA2R1 and pave the way for its use as a reliable biomarker and an attractive therapeutic target in these diseases.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Autoantibodies / physiology
  • Genes, Tumor Suppressor
  • Glomerulonephritis, Membranous / genetics*
  • Glomerulonephritis, Membranous / immunology
  • Glomerulonephritis, Membranous / metabolism
  • Humans
  • Inflammation / genetics
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Phospholipases A2 / metabolism
  • Receptors, Phospholipase A2 / chemistry
  • Receptors, Phospholipase A2 / physiology*


  • Autoantibodies
  • PLA2R1 protein, human
  • Receptors, Phospholipase A2
  • Phospholipases A2