Antihyperlipidemic effect of fisetin, a bioflavonoid of strawberries, studied in streptozotocin-induced diabetic rats

J Biochem Mol Toxicol. 2014 Oct;28(10):442-9. doi: 10.1002/jbt.21583. Epub 2014 Jun 17.


Chronic hyperglycemia in diabetes is associated with profound changes in lipid and lipoprotein metabolism, with resultant alterations in particle distribution within lipoprotein classes. In the present study, an attempt has been made to explore the antihyperlipidemic effect of fisetin in streptozotocin-induced experimental diabetes in rats. Upon fisetin treatment to diabetic rats, the levels of blood glucose were significantly reduced with an improvement in plasma insulin. The increased levels of lipid contents in serum, hepatic, and renal tissues observed in diabetic rats were normalized upon fisetin administration. Also, the decreased levels of high-density lipoprotein cholesterol, and increased levels of low-density lipoprotein (LDL) and very LDL (VLDL) cholesterol in serum of diabetic rats were normalized. Oil Red O staining established a large number of intracellular lipid droplets accumulation in the diabetic rats. Fisetin treatment exacerbated the degree of lipid accumulation. The results of the present study exemplify the antihyperlipidemic property of the fisetin.

Keywords: Antihyperlipidemic Property; Diabetes; Fisetin; Streptozotocin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Blood Glucose / drug effects
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Flavonoids / therapeutic use*
  • Flavonols
  • Hypolipidemic Agents / therapeutic use*
  • Insulin / blood
  • Kidney / drug effects
  • Lipids / analysis
  • Lipoproteins, HDL / blood
  • Lipoproteins, HDL / drug effects
  • Lipoproteins, LDL / blood
  • Lipoproteins, LDL / drug effects
  • Liver / drug effects
  • Male
  • Rats
  • Rats, Wistar


  • Blood Glucose
  • Flavonoids
  • Flavonols
  • Hypolipidemic Agents
  • Insulin
  • Lipids
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • fisetin