Clinical grade purification and expansion of natural killer cells

Crit Rev Oncog. 2014;19(1-2):121-32. doi: 10.1615/critrevoncog.2014010931.

Abstract

Natural killer (NK) cells have been shown to have important functions in anti-tumor responses and therefore have been used as adoptive immunotherapy for cancer. Here, we review the current methods of ex vivo activation, enrichment, expansion, and shipment of clinical NK cell products.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Humans
  • Killer Cells, Natural / immunology*
  • Neoplasms / immunology*