Forskolin inhibits platelet deposition in small diameter polytetrafluoroethylene grafts

J Cardiovasc Surg (Torino). Jan-Feb 1989;30(1):81-4.

Abstract

Synthetic vascular grafts have a thrombogenic surface which probably is an important factor in graft failure. Systemic pharmacologic intervention has been used but is associated with side effects. In this communication we describe the results of a new therapeutic principle of applying forskolin, a powerful cyclic adenosine monophosphate stimulator (cAMP), to the inner surface of a synthetic graft material, polytetrafluoroethylene. Evaluation was done with Indium-111-oxine labelled platelets and histopathology. It was found that forskolin significantly lowers the platelet deposition onto the treated graft surface compared to controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Flow Velocity
  • Blood Platelets / drug effects
  • Blood Platelets / physiology*
  • Blood Vessel Prosthesis*
  • Colforsin / administration & dosage
  • Colforsin / pharmacology*
  • Indium Radioisotopes
  • Male
  • Organometallic Compounds
  • Oxyquinoline / analogs & derivatives
  • Polytetrafluoroethylene*
  • Sheep
  • Vascular Patency

Substances

  • Indium Radioisotopes
  • Organometallic Compounds
  • indium oxine
  • Colforsin
  • Oxyquinoline
  • Polytetrafluoroethylene