Pink1, the first ubiquitin kinase

EMBO J. 2014 Aug 1;33(15):1621-3. doi: 10.15252/embj.201489185. Epub 2014 Jun 18.

Abstract

Pink1 and Parkin, identified through studies of hereditary early onset Parkinson's disease, are involved in mitochondria quality control. Parkin E3 ubiquitin ligase activity is activated by Pink1 kinase activity, although the mechanism is still elusive. Three recent reports uncover a surprising mechanism in which Pink1 directly phosphorylates ubiquitin to boost Parkin activity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Serine / metabolism
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Ubiquitin
  • Serine
  • Ubiquitin-Protein Ligases
  • parkin protein
  • Protein Kinases
  • PTEN-induced putative kinase