Wnt-Notch signalling crosstalk in development and disease

Cell Mol Life Sci. 2014 Sep;71(18):3553-67. doi: 10.1007/s00018-014-1644-x. Epub 2014 Jun 19.


The Notch and Wnt pathways are two of only a handful of highly conserved signalling pathways that control cell-fate decisions during animal development (Pires-daSilva and Sommer in Nat Rev Genet 4: 39-49, 2003). These two pathways are required together to regulate many aspects of metazoan development, ranging from germ layer patterning in sea urchins (Peter and Davidson in Nature 474: 635-639, 2011) to the formation and patterning of the fly wing (Axelrod et al in Science 271:1826-1832, 1996; Micchelli et al in Development 124:1485-1495, 1997; Rulifson et al in Nature 384:72-74, 1996), the spacing of the ciliated cells in the epidermis of frog embryos (Collu et al in Development 139:4405-4415, 2012) and the maintenance and turnover of the skin, gut lining and mammary gland in mammals (Clayton et al in Nature 446:185-189, 2007; Clevers in Cell 154:274-284, 2013; Doupe et al in Dev Cell 18:317-323, 2010; Lim et al in Science 342:1226-1230, 2013; Lowell et al in Curr Biol 10:491-500, 2000; van et al in Nature 435:959-963, 2005; Yin et al in Nat Methods 11:106-112, 2013). In addition, many diseases, including several cancers, are caused by aberrant signalling through the two pathways (Bolós et al in Endocr Rev 28: 339-363, 2007; Clevers in Cell 127: 469-480, 2006). In this review, we will outline the two signalling pathways, describe the different points of interaction between them, and cover how these interactions influence development and disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Lineage
  • Drosophila / growth & development
  • Drosophila / metabolism
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Mammals / growth & development
  • Mammals / metabolism
  • Models, Biological*
  • Receptors, Notch / metabolism
  • Receptors, Notch / physiology*
  • Signal Transduction
  • Wnt Signaling Pathway*


  • Receptors, Notch