Imaging preclinical tumour models: improving translational power

Nat Rev Cancer. 2014 Jul;14(7):481-93. doi: 10.1038/nrc3751. Epub 2014 Jun 19.


Recent developments and improvements of multimodal imaging methods for use in animal research have substantially strengthened the options of in vivo visualization of cancer-related processes over time. Moreover, technological developments in probe synthesis and labelling have resulted in imaging probes with the potential for basic research, as well as for translational and clinical applications. In addition, more sophisticated cancer models are available to address cancer-related research questions. This Review gives an overview of developments in these three fields, with a focus on imaging approaches in animal cancer models and how these can help the translation of new therapies into the clinic.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Molecular Imaging / instrumentation
  • Molecular Imaging / methods*
  • Neoplasms / diagnosis*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / therapy
  • Translational Medical Research*