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. 2014 Apr 18;3(4):349-50.
doi: 10.1016/j.molmet.2014.04.002. eCollection 2014 Jul.

mTORC2, the "Other" mTOR, Is a New Player in Energy Balance Regulation

Free PMC article

mTORC2, the "Other" mTOR, Is a New Player in Energy Balance Regulation

Daniela Cota. Mol Metab. .
Free PMC article


Figure 1
Figure 1
Simplified scheme illustrating the regulation of the mTOR pathway in the brain. For further details on upstream regulators of mTORC1 and mTORC2 and their downstream molecular targets the reader should refer to Ref. . IRS-1, insulin receptor substrate 1; PTEN, phosphatase and tensin homolog; PDK1, phosphatidylinositol-dependent kinase 1; Rheb, Ras homolog enriched in brain.

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    1. Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell. 2012;149(2):274–293. - PMC - PubMed
    1. Costa-Mattioli M., Monteggia L.M. mTOR complexes in neurodevelopmental and neuropsychiatric disorders. Nature Neuroscience. 2013;16(11):1537–1543. - PubMed
    1. Cota D., Proulx K., Smith K.A., Kozma S.C., Thomas G., Woods S.C. Hypothalamic mTOR signaling regulates food intake. Science. 2006;312(5775):927–930. - PubMed
    1. Martínez de Morentin P.B., Martinez-Sanchez N., Roa J., Ferno J., Nogueiras R., Tena-Sempere M. Hypothalamic mTOR: the rookie energy sensor. Current Molecular Medicine. 2014;14(1):3–21. - PubMed
    1. Kocalis H.E., Hagan S.L., George L., Turney M.K., Siuta M.A., Laryea G.N. Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. Molecular Metabolism. 2014 [in press] - PMC - PubMed