Association of circulating C1q/TNF-related protein 1 levels with coronary artery disease in men

PLoS One. 2014 Jun 19;9(6):e99846. doi: 10.1371/journal.pone.0099846. eCollection 2014.


Objective: Obesity is a major risk factor for cardiovascular disease. Recent evidence demonstrates that dysregulation of fat-derived hormones, also known as adipokines, is linked with the pathogenesis of obesity-related disorders including coronary artery disease (CAD). Here, we investigated whether circulating level of an adipokine C1q/TNF-related protein (CTRP) 1 is associated with the prevalence of CAD.

Methods and results: Consecutive 76 male CAD patients were enrolled from inpatients that underwent coronary angiography. Sixty four healthy male subjects served as controls. Plasma CTRP1 concentration was determined by enzyme-linked immunosorbent assay. CTRP1 levels were correlated positively with systolic blood pressure (BP) and triglyceride levels, and negatively with HDL cholesterol levels in all subjects. Plasma levels of CTRP1 were significantly higher in CAD patients than in control subjects (CAD: 443.3±18.6 ng/ml, control: 307.8±21.5 ng/ml, p<0.001). Multiple logistic regression analysis with body mass index, systolic BP, glucose, total cholesterol, HDL cholesterol, triglyceride, adiponectin and CTRP1 revealed that CTRP1 levels, together with systolic BP and HDL cholesterol, correlated with CAD.

Conclusions: Our data indicate the close association of high CTRP1 levels with CAD prevalence, suggesting that CTRP1 represents a novel biomarker for CAD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood
  • Aged
  • Biomarkers / blood
  • Blood Pressure
  • Body Mass Index
  • Case-Control Studies
  • Cholesterol, HDL / blood
  • Coronary Angiography
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / physiopathology
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Proteins / metabolism*
  • Triglycerides / blood


  • Adiponectin
  • Biomarkers
  • C1QTNF1 protein, human
  • Cholesterol, HDL
  • Proteins
  • Triglycerides

Grants and funding

This work was supported by Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research and grants from Takeda Science Foundation, the Uehara Memorial Foundation, Daiichi-Sankyo Foundation of Life Science, and SENSHIN Medical Research Foundation to N. Ouchi. R. Shibata was supported with the Grant-in-Aid for Young Scientists B and the Uehara Memorial Foundation. K. Ohashi was supported with the Grant-in-Aid for Scientific Research C and Suzuken Memorial Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.