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. 2014 Aug;47:70-6.
doi: 10.1016/j.reprotox.2014.06.002. Epub 2014 Jun 16.

Prenatal and Peripubertal Phthalates and Bisphenol A in Relation to Sex Hormones and Puberty in Boys

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Free PMC article

Prenatal and Peripubertal Phthalates and Bisphenol A in Relation to Sex Hormones and Puberty in Boys

Kelly K Ferguson et al. Reprod Toxicol. .
Free PMC article

Abstract

Phthalates and BPA are known endocrine disruptors and exposure in pregnant mothers and children is ubiquitous. We explored the relationship of prenatal and childhood exposures with pubertal onset and sex hormones in boys (ages 8-14). Phthalate metabolites and BPA were measured in maternal 3rd trimester or childhood urine. Sex hormones DHEAS, estradiol, inhibin B, SHBG, and total testosterone were measured in serum. Adrenarche and puberty were assessed by pediatrician. Prenatal exposure to some phthalates was associated with decreased DHEAS and inhibin B levels, and with increased SHBG. Prenatal exposure to most phthalates and BPA was associated with greatly reduced odds of adrenarche (odds ratios [OR]=0.12-0.65) and slightly reduced odds of puberty (OR=0.50-0.98). Childhood exposure was not associated with adrenarche or puberty, but some phthalates and BPA were associated with increased SHBG levels and decreased total and free testosterone levels.

Keywords: Bisphenol A; Environment; Exposure; Puberty; Tanner stage; Testosterone.

Conflict of interest statement

Conflict of interest

The authors declare that they have no conflicts of interest.

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