Phytotoxic cis-clerodane diterpenoids from the Chinese liverwort Scapania stephanii

Phytochemistry. 2014 Sep:105:85-91. doi: 10.1016/j.phytochem.2014.05.019. Epub 2014 Jun 16.

Abstract

Five cis-clerodane diterpenoids, stephanialides A-E, along with seven known cis-clerodanes, scaparvins A-C, parvitexins B and C, 3-chloro-4-hydroxy-parvitexin A, and scapanialide B, were isolated from the Chinese liverwort Scapania stephanii. Their structures were established unequivocally on the basis of spectroscopic data. The absolute configuration of stephanialide A was determined by analysis of CD data using the octant rule. Phytotoxic activity evaluation showed that this type of diterpenoids can significantly inhibit root elongation of the seeds of Arabidopsis thaliana, Lepidium sativum and Brassica pekinensis.

Keywords: Bryophytes; Liverworts; Phytotoxic activities; Scapania stephanii; Scapaniaceae; Stephanialides A−E; cis-Clerodane diterpenoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arabidopsis / drug effects
  • Brassica / drug effects
  • Crystallography, X-Ray
  • Diterpenes, Clerodane / chemistry
  • Diterpenes, Clerodane / isolation & purification*
  • Diterpenes, Clerodane / pharmacology*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Hepatophyta / chemistry*
  • Lepidium sativum / drug effects
  • Molecular Structure
  • Plant Roots / drug effects
  • Plant Roots / growth & development
  • Seeds / drug effects
  • Seeds / growth & development
  • Stereoisomerism

Substances

  • Diterpenes, Clerodane
  • Drugs, Chinese Herbal