Comparison of autogeneous and homogeneous nasal dorsal onlay grafts in an experimental design

Eur Arch Otorhinolaryngol. 2015 Mar;272(3):619-25. doi: 10.1007/s00405-014-3142-z. Epub 2014 Jun 20.

Abstract

An experimental model was used for the comparative evaluation of autogeneous and homogeneous nasal dorsal onlay cartilage grafts. This study was conducted on 18 adult white New Zealand male rabbits. Nasal septal cartilage (NSC), sliced nasal septal cartilage (SNSC) and auricular cartilage (AC) grafts were prepared in autogeneous and homogeneous forms and placed into the subcutaneous pockets of the nasal dorsum of rabbits. After a period of 3 months, the animals were painlessly killed, and each site was analyzed histologically for inflammation, neovascularization, fibrosis and resorption. Inflammation, fibrosis and neovascularization were found to be significantly more extensive in the homogeneous graft groups and autogeneous SNSC group 3 months after implantation. Resorption was significantly high in both homogeneous and autogeneous AC groups and significantly low in the autogeneous and homogeneous SNSC groups. There was no significant difference between the homogeneous and autogeneous grafts in terms of resorption rates. In conclusion, the results of this experimental study demonstrate that resorption was lesser than expected in the sliced cartilage graft and that homologous cartilage graft applications had activity and reliability similar to that of autogenous cartilage grafts.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Ear Cartilage / transplantation
  • Fibrosis / pathology
  • Inflammation / pathology
  • Male
  • Models, Animal
  • Nasal Cartilages / transplantation*
  • Neovascularization, Pathologic / pathology
  • Rabbits
  • Transplantation, Autologous