High-throughput production of two disulphide-bridge toxins

Chem Commun (Camb). 2014 Aug 7;50(61):8408-11. doi: 10.1039/c4cc02679a.


A quick and efficient production method compatible with high-throughput screening was developed using 36 toxins belonging to four different families of two disulphide-bridge toxins. Final toxins were characterized using HPLC co-elution, CD and pharmacological studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Chromatography, High Pressure Liquid
  • Circular Dichroism
  • Disulfides / chemistry*
  • Molecular Sequence Data
  • Toxins, Biological / chemistry
  • Toxins, Biological / classification
  • Toxins, Biological / metabolism*


  • Disulfides
  • Toxins, Biological