The roles of biomarkers of oxidative stress and antioxidant in Alzheimer's disease: a systematic review

Biomed Res Int. 2014;2014:182303. doi: 10.1155/2014/182303. Epub 2014 May 14.


Purpose: Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies.

Methods: PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD.

Results and conclusion: Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Alzheimer Disease / blood*
  • Animals
  • Antioxidants / metabolism*
  • Biomarkers / blood
  • Humans
  • Lipid Peroxidation*
  • Oxidative Stress*
  • PubMed


  • Antioxidants
  • Biomarkers