Sarcolipin provides a novel muscle-based mechanism for adaptive thermogenesis

Exerc Sport Sci Rev. 2014 Jul;42(3):136-42. doi: 10.1249/JES.0000000000000016.

Abstract

The sarco(endo)plasmic reticulum Ca-ATPase (SERCA) transports Ca into the sarcoplasmic reticulum lumen and contributes significantly to skeletal muscle metabolic rate. Sarcolipin (SLN) has been shown recently to uncouple Ca transport from adenosine triphosphate hydrolysis by SERCA. We have hypothesized that SLN provides a novel mechanism of adaptive thermogenesis within skeletal muscle and protects against diet-induced obesity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue, Brown / metabolism
  • Animals
  • Basal Metabolism
  • Biological Transport
  • Calcium / metabolism
  • Humans
  • Ion Channels / metabolism
  • Mitochondrial Proteins / metabolism
  • Muscle Proteins / metabolism*
  • Proteolipids / metabolism*
  • Sarcoplasmic Reticulum / metabolism*
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism*
  • Thermogenesis*
  • Uncoupling Protein 1

Substances

  • Ion Channels
  • Mitochondrial Proteins
  • Muscle Proteins
  • Proteolipids
  • Uncoupling Protein 1
  • sarcolipin
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases
  • Calcium