The search for antiaging interventions: from elixirs to fasting regimens

Cell. 2014 Jun 19;157(7):1515-26. doi: 10.1016/j.cell.2014.05.031.


The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial. Recent evidence is shaping a picture where low caloric regimes and exercise may improve healthy senescence, and several pharmacological strategies have been suggested to counteract aging. Surprisingly, the most effective interventions proposed to date converge on only a few cellular processes, in particular nutrient signaling, mitochondrial efficiency, proteostasis, and autophagy. Here, we critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / drug effects*
  • Animals
  • Antioxidants / administration & dosage
  • Autophagy
  • Diet
  • Exercise
  • Humans
  • Longevity / drug effects
  • Signal Transduction


  • Antioxidants