A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments

Biochem Biophys Res Commun. 1989 Mar 31;159(3):1221-6. doi: 10.1016/0006-291x(89)92240-7.


Tau, a microtubule-associated phosphoprotein, was identified as a definite component of paired helical filaments which progressively accumulate in Alzheimer's disease brain. To learn more about tau in the aged brain, we have isolated and sequenced a cDNA clone encoding tau from a cDNA library of an aged human brain. The cloned cDNA sequence included a new insert of 93 nucleotides, which added a fourth repeat to the three-repeat type of tau already reported. Perhaps, this four-repeat type of tau is predominant in normal aged brain. In contrast, the sequence analysis of paired helical filaments showed that the integrated tau is of three-repeat type. This indicates that a distinct form of tau is selectively incorporated into paired helical filaments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Amino Acid Sequence
  • Base Sequence
  • Cerebral Cortex / metabolism
  • Cloning, Molecular
  • DNA / genetics
  • Humans
  • Microtubule-Associated Proteins / genetics*
  • Microtubule-Associated Proteins / isolation & purification
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics*
  • Reference Values
  • tau Proteins


  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • tau Proteins
  • DNA

Associated data

  • GENBANK/M25298