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Review
. 2014 Aug;16(8):513.
doi: 10.1007/s11886-014-0513-4.

Biomarkers of Coronary Artery Disease: The Promise of the Transcriptome

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Free PMC article
Review

Biomarkers of Coronary Artery Disease: The Promise of the Transcriptome

Marten Antoon Siemelink et al. Curr Cardiol Rep. .
Free PMC article

Abstract

The last years have witnessed tremendous technical advances in the field of transcriptomics that enable the simultaneous assessment of nearly all transcripts expressed in a tissue at a given time. These advances harbor the potential to gain a better understanding of the complex biological systems and for the identification and development of novel biomarkers. This article will review the current knowledge of transcriptomics biomarkers in the cardiovascular field and will provide an overview about the promises and challenges of the transcriptomics approach for biomarker identification.

Figures

Fig. 1
Fig. 1
Challenges in transcriptomic biomarker development. Figure depicts main steps in Biomarker discovery and development and associated challenges to overcome
Fig. 2
Fig. 2
Transcriptomics for biomarker discovery. Simplified schematic of relevant transcriptome interactions for current biomarker development. Large studies are required to elucidate the complex interactions of the genome and epigenome with the transcriptome and subsequently the proteome. Bullets denote contemporary techniques. eQTL, expression quantitative trait loci; meQTL, methylation quantitative trait loci; mRNA, messenger RNA; ncRNA, non-coding RNA

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