Role of assisted hatching in in vitro fertilization: a guideline

Fertil Steril. 2014 Aug;102(2):348-51. doi: 10.1016/j.fertnstert.2014.05.034. Epub 2014 Jun 18.


There is good evidence that assisted hatching (AH) slightly improves clinical pregnancy rates, particularly in poor prognosis patients, including those with prior failed in vitro fertilization (IVF) cycles. Due to a limited number of studies, there is insufficient evidence to conclude that AH improves live-birth rates. This document replaces the 2008 American Society for Reproductive Medicine and Society for Assisted Reproductive Technology Practice Committees' document titled, "Assisted hatching in in vitro fertilization: a review of the literature. A committee opinion" (Fertil Steril 2008;90[Suppl 5]:S196-8).

Publication types

  • Practice Guideline
  • Review

MeSH terms

  • Female
  • Fertility*
  • Fertilization in Vitro / adverse effects
  • Fertilization in Vitro / methods
  • Fertilization in Vitro / standards*
  • Humans
  • Infertility / diagnosis
  • Infertility / physiopathology
  • Infertility / therapy*
  • Live Birth
  • Male
  • Pregnancy
  • Pregnancy Rate
  • Risk Factors
  • Treatment Outcome