Leucocyte adhesion deficiency III in a mixed-breed dog

Aust Vet J. 2014 Aug;92(8):299-302. doi: 10.1111/avj.12206. Epub 2014 Jun 23.


Background: Leucocyte adhesion deficiencies are inherited disorders characterised by immunodeficiency leading to recurrent infections and a marked leucocytosis. We describe the clinical characteristics, diagnosis and management of an Australian mixed- breed dog with leucocyte adhesion deficiency III.

Case report: A 16-month-old male, neutered, German Shepherd × Rottweiler dog was investigated for pyrexia, persistent leucocytosis, marked periodontal disease, lameness, increased mucosal haemorrhages and poor wound healing. Numerous diagnostics were performed including a leucocyte adhesion deficiency III PCR test, which was positive. The patient was managed with topical pressure at bleeding sites, antibiotics, analgesics and dental prophylaxis when required.

Discussion: Leucocyte adhesion deficiency III is a rare disorder that manifests because of impaired activation of beta integrins. This results in an absence of neutrophil chemotaxis and adhesion, and platelet dysfunction. Mutations within the KINDLIN3 gene resulting in the absence of the kindlin-3 protein have been identified as the cause of this disease. Leucocyte adhesion deficiency III has previously been reported in humans and a German Shepherd dog. This report describes the first reported case of leucocyte adhesion deficiency III in Australia and the first reported case in a mixed-breed dog worldwide.

Keywords: KINDLIN3; immunodeficiency; leucocyte adhesion deficiencies; neutrophils; platelets.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Dog Diseases / blood
  • Dog Diseases / diagnosis
  • Dog Diseases / immunology*
  • Dogs / immunology
  • Leukocyte-Adhesion Deficiency Syndrome / blood
  • Leukocyte-Adhesion Deficiency Syndrome / diagnosis
  • Leukocyte-Adhesion Deficiency Syndrome / immunology
  • Leukocyte-Adhesion Deficiency Syndrome / veterinary*
  • Male
  • Polymerase Chain Reaction / veterinary

Supplementary concepts

  • Leukocyte Adhesion Deficiency, Type III