Urea for management of the syndrome of inappropriate secretion of ADH: A systematic review

Endocrinol Nutr. 2014 Nov;61(9):486-92. doi: 10.1016/j.endonu.2014.04.006. Epub 2014 Jun 19.
[Article in English, Spanish]


Urea has been recently proposed for the management of hyponatremia linked to the syndrome of inappropriate secretion of ADH (SIADH). The objective of the study was to review the levels of evidence for treatment of hyponatremia associated with SIADH with urea. We performed a: systematic review of experimental trials and grading according to SIGN. No clinical trials were found. The 6 studies analysed had methodological limitations and were prone to biases. In conclusion, there is no evidence to support the efficacy of urea for the treatment of hyponatremia following SIADH.

Keywords: Hiponatremia; Hyponatremia; Revisión sistemática; Sindrome secreción inadecuada hormona antidiurètica; Syndrome of inappropriate secretion of antidiuretic hormone; Systematic review; Urea.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Disease Management
  • Drug Evaluation
  • Evidence-Based Medicine
  • Humans
  • Hypernatremia / chemically induced
  • Hypokalemia / chemically induced
  • Hyponatremia / drug therapy
  • Hyponatremia / etiology
  • Inappropriate ADH Syndrome / complications
  • Inappropriate ADH Syndrome / drug therapy*
  • Observational Studies as Topic
  • Prospective Studies
  • Research Design
  • Treatment Outcome
  • Urea / adverse effects
  • Urea / therapeutic use*


  • Urea