[Composition and antitumor activities of essential oil from the fruits of Dasymaschalon trichophorum]

Zhong Yao Cai. 2013 Nov;36(11):1786-8.
[Article in Chinese]


Objective: To study the chemical components and antitumor activities of essential oil from the fruits of Dasymaschalon trichophorum.

Methods: The essential oil from the fruits of Dasymaschalon trichophorum was extracted by steam-stilling and analyzed by GC-MS. The inhibitory effect of extract of Dasymaschalon trichophorum on SPCA-1,BEL-7402, SGC-7901 and K-562 cell proliferation was assayed using the MTU.

Results: GC-MS result showed that there were 55 peaks and 30 compounds were identified which weighed 74.98%. The major components were nerolidol (19.887%), caryophyllene (16.714%) and beta-myrcene (9.29%). The essential oil exhibited strong antitumor activity against SPCA-1 human tumor cell line with IC50 value of 6.61 microg/mL.

Conclusion: This experiment provides scientific foundation for further utilization of Dasymaschalon trichophorum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclic Monoterpenes
  • Annonaceae / chemistry*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Fruit / chemistry
  • Gas Chromatography-Mass Spectrometry
  • Hot Temperature
  • Humans
  • Inhibitory Concentration 50
  • Monoterpenes / analysis
  • Oils, Volatile / chemistry*
  • Oils, Volatile / isolation & purification
  • Oils, Volatile / pharmacology*
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / analysis


  • Acyclic Monoterpenes
  • Antineoplastic Agents, Phytogenic
  • Monoterpenes
  • Oils, Volatile
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • beta-myrcene
  • caryophyllene
  • nerolidol