Neuronal activity-dependent regulation of MicroRNAs

Mol Cells. 2014 Jul;37(7):511-7. doi: 10.14348/molcells.2014.0132. Epub 2014 Jun 24.


MicroRNAs are non-coding short (~23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA regulation has been less focused. Neuronal activity-dependent regulation of miRNA may fine-tune gene expression in response to synaptic plasticity and memory formation. Here, we provide an overview of miRNA regulation by neuronal activity including high-throughput screening studies. We also discuss the possible molecular mechanisms of activity-dependent induction and turnover of miRNAs.

Keywords: NMDAR; high-throughput screening; miRNA induction; miRNA turnover; neuronal activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • High-Throughput Screening Assays
  • Humans
  • Memory* / physiology
  • MicroRNAs / physiology*
  • Neuronal Plasticity* / genetics
  • Neurons / physiology*
  • RNA Interference*


  • MicroRNAs