Jumping-like translocation-a rare chromosomal rearrangement in a patient with Burkitt lymphoma/leukemia

Cancer Genet. 2014 May;207(5):221-5. doi: 10.1016/j.cancergen.2014.05.001. Epub 2014 May 10.


Chromosomal translocations are acquired genetic rearrangements in human cancers. Jumping translocations are rare nonreciprocal rearrangements involving the same donor chromosome segment translocated to two or more recipient chromosomes. In this report, we describe a patient with Burkitt lymphoma/leukemia (BL) and a complex karyotype including a t(2;8)(p12;q24), copy-neutral loss of heterozygosity at 17p13.1-p13.3 and 19q13.1-q13.2, trisomy 20, and two uncommon chromosomal aberrations. The first uncommon aberration was a complex rearrangement of chromosome 15 (probably the consequence of chromothripsis) masked by an apparently balanced reciprocal translocation, t(11;15)(p11.2;q21). The second one was a special type of unbalanced "vice versa" jumping translocation, which involved the same acceptor chromosome arm (13q) and various donor chromosome segments. It is unclear whether both atypical rearrangements are the consequence of the TP53 alteration or whether assumed chromothripsis influenced the development of the jumping-like translocation. However, the presence of the t(11;15)(p11.2;q21) in all pathological cells suggests that it occurred in the early stage of the disease, whereas the jumping-like translocation, as an additional change, subsequently accelerated the progression of the disease.

Keywords: 13q deletion; Burkitt lymphoma/leukemia; FISH; chromothripsis; jumping translocation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Burkitt Lymphoma / diagnosis
  • Burkitt Lymphoma / genetics*
  • Chromosome Deletion
  • Chromosome Disorders / genetics
  • Chromosomes, Human, Pair 11 / genetics
  • Chromosomes, Human, Pair 13 / genetics
  • Chromosomes, Human, Pair 15 / genetics
  • Chromosomes, Human, Pair 20 / genetics
  • Female
  • Humans
  • Mosaicism
  • Translocation, Genetic*
  • Trisomy / genetics
  • Tumor Suppressor Protein p53 / genetics


  • TP53 protein, human
  • Tumor Suppressor Protein p53

Supplementary concepts

  • 13q deletion syndrome
  • Chromosome 20, trisomy