The role of animal models in tendon research

M W Hast; A Zuskov; L J Soslowsky

doi:10.1302/2046-3758.36.2000281

The role of animal models in tendon research

Bone Joint Res. 2014 Jun;3(6):193-202. doi: 10.1302/2046-3758.36.2000281.

Authors

M W Hast¹, A Zuskov¹, L J Soslowsky¹

Affiliation

¹ University of Pennsylvania, McKay Orthopaedic Research Laboratory, 424 Stemmler Hall 36th Street and Hamilton Walk, Philadelphia, 19104-6081, USA.

Abstract

Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are often used in this field of research as they offer an attractive framework to examine the cascade of processes that occur throughout both tendon pathology and repair. This review discusses the structural, mechanical, and biological changes that occur throughout tendon pathology in animal models, as well as strategies for the improvement of tendon healing. Cite this article: Bone Joint Res 2014;3:193-202.

Keywords: Animal Model; Literature Review; Tendinopathy; Tendon.

Publication types

Review

Grants and funding

L. J. Soslowsky reports that his institution, the University of Pennsylvania, has received grants from DJO and Amniox, neither of which is related to this article.