A marked rise in 5-S-cysteinyl-dopamine levels in guinea-pig striatum following reserpine treatment

J Neural Transm. 1989;76(2):155-61. doi: 10.1007/BF01578755.


Reserpine administration (5 mg/kg, i.p.) to guinea pigs resulted in marked and long lasting dopamine (DA) depletion and a rapid, short lasting, increase of 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. A marked and sustained increase of the level of 5-S-cysteinyl-dopamine, which is an adduct presumably formed following autoxidation of DA, started 3-4 h following the DA and DOPAC changes. Only small changes in the levels of the 5-S-cysteinyl adducts of DOPAC and 3,4-dihydroxyphenylalanine (DOPA) were found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Cysteinyldopa / metabolism*
  • Dihydroxyphenylalanine / analogs & derivatives*
  • Dopamine / metabolism*
  • Female
  • Guinea Pigs
  • Reserpine / pharmacology*


  • 3,4-Dihydroxyphenylacetic Acid
  • Cysteinyldopa
  • Dihydroxyphenylalanine
  • Reserpine
  • Dopamine