CAS proteins in health and disease: an update

IUBMB Life. 2014 Jun;66(6):387-95. doi: 10.1002/iub.1282. Epub 2014 Jun 24.


The CAS family of scaffolding proteins has increasingly attracted scrutiny as important for regulation of cancer-associated signaling. BCAR1 (also known as p130Cas), NEDD9 (HEF1, Cas-L), EFS (Sin), and CASS4 (HEPL) are regulated by and mediate cell attachment, growth factor, and chemokine signaling. Altered expression and activity of CAS proteins are now known to promote metastasis and drug resistance in cancer, influence normal development, and contribute to the pathogenesis of heart and pulmonary disease. In this article, we provide an update on recently published studies describing signals regulating and regulated by CAS proteins, and evidence for biological activity of CAS proteins in normal development, cancer, and other pathological conditions.

Keywords: human molecular disease; protein function; signal transduction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism
  • Cell Adhesion / physiology*
  • Cell Differentiation / physiology*
  • Chemokines / metabolism
  • Crk-Associated Substrate Protein / metabolism*
  • Crk-Associated Substrate Protein / physiology*
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Muscle Development / physiology*
  • Neoplasms / metabolism*
  • Phosphorylation
  • Signal Transduction / physiology*


  • Actins
  • Chemokines
  • Crk-Associated Substrate Protein
  • Intercellular Signaling Peptides and Proteins