Bifidobacterium animalis ssp. lactis BI07 modulates the tumor necrosis factor alpha-dependent imbalances of the enterocyte-associated intestinal microbiota fraction

FEMS Microbiol Lett. 2014 Aug;357(2):157-63. doi: 10.1111/1574-6968.12515. Epub 2014 Jul 14.


Using a previously developed in vitro model to characterize the enterocyte-adherent microbiota fraction, we explored the potential of the probiotic strain Bifidobacterium animalis ssp. lactis BI07 to modulate the inflammation-dependent dysbioses of the enterocyte-adherent microbiota from 12 healthy human donors. According to our findings, B. animalis ssp. lactis BI07 is effective in limiting the increase of pro-inflammatory pathobionts on the inflamed mucosal site, supporting the recovery of a mutualistic community.

Keywords: Bifidobacterium lactis; gut inflammation; gut microbiota; probiotics.

Publication types

  • Letter

MeSH terms

  • Adult
  • Bifidobacterium / immunology*
  • Dysbiosis / immunology
  • Enterocytes / immunology*
  • Enterocytes / microbiology*
  • Gastrointestinal Tract / immunology*
  • Gastrointestinal Tract / microbiology*
  • Humans
  • Tumor Necrosis Factor-alpha / immunology*
  • Young Adult


  • TNF protein, human
  • Tumor Necrosis Factor-alpha