Aspartame and Risk of Cancer: A Meta-analytic Review

Arch Environ Occup Health. 2015;70(3):133-41. doi: 10.1080/19338244.2013.828674.


Aspartame (APM) is the most commonly used artificial sweetener and flavor enhancer in the world. There is a rise in concern that APM is carcinogenic due to a variation in the findings of the previous APM carcinogenic bioassays. This article conducts a meta-analytic review of all previous APM carcinogenic bioassays on rodents that were conducted before 31 December 2012. The search yielded 10 original APM carcinogenic bioassays on rodents. The aggregate effect sizes suggest that APM consumption has no significant carcinogenic effect in rodents.

Keywords: aspartame; cancer; meta-analysis.

Publication types

  • Meta-Analysis

MeSH terms

  • Aspartame / toxicity*
  • Humans
  • Neoplasms / chemically induced
  • Neoplasms / epidemiology*
  • Risk Assessment
  • Sweetening Agents / toxicity*


  • Sweetening Agents
  • Aspartame