Treatment of gonococcal conjunctivitis with single-dose intramuscular ceftriaxone

Am J Ophthalmol. 1989 May 15;107(5):511-4. doi: 10.1016/0002-9394(89)90495-9.


We treated 13 consecutive patients with culture proven Neisseria gonorrhoeae conjunctivitis with single-dose intramuscular injections of ceftriaxone. Pretreatment conjunctival cultures and Gram stains were obtained from all patients. The patients were admitted for antibiotic administration, a single conjunctival saline lavage, and follow-up conjunctival cultures six and 12 hours after treatment. Three of 13 organisms (23%) were penicillinase producing. All patients responded to treatment, and all six- and 12-hour posttreatment cultures were negative for N. gonorrhoeae. These results indicate that a single intramuscular dose of ceftriaxone is curative treatment for non-neonatal gonococcal conjunctivitis.

MeSH terms

  • Adolescent
  • Adult
  • Ceftriaxone / administration & dosage*
  • Child
  • Child, Preschool
  • Conjunctiva / microbiology
  • Conjunctivitis, Bacterial / drug therapy*
  • Conjunctivitis, Bacterial / microbiology
  • Drug Evaluation
  • Female
  • Gonorrhea / drug therapy*
  • Humans
  • Infant
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Neisseria gonorrhoeae / isolation & purification
  • Time Factors


  • Ceftriaxone