Hypomagnesemia: a clinical perspective

Int J Nephrol Renovasc Dis. 2014 Jun 9:7:219-30. doi: 10.2147/IJNRD.S42054. eCollection 2014.


Although magnesium is involved in a wide spectrum of vital functions in normal human physiology, the significance of hypomagnesemia and necessity for its treatment are under-recognized and underappreciated in clinical practice. In the current review, we first present an overview of the clinical significance of hypomagnesemia and normal magnesium metabolism, with a focus on renal magnesium handling. Subsequently, we review the literature for both congenital and acquired hypomagnesemic conditions that affect the various steps in normal magnesium metabolism. Finally, we present an approach to the routine evaluation and suggested management of hypomagnesemia.

Keywords: TRPM6; alcohol; cisplatin; diabetes mellitus; hypomagnesemia; magnesium.

Publication types

  • Review