Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population

Emel Saglar; Banu Bozkurt; Murat Irkec

doi:10.3980/j.issn.2222-3959.2014.03.07

Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population

Int J Ophthalmol. 2014 Jun 18;7(3):426-30. doi: 10.3980/j.issn.2222-3959.2014.03.07. eCollection 2014.

Authors

Emel Saglar¹, Banu Bozkurt², Murat Irkec³

Affiliations

¹ Department of Molecular Biology, Faculty of Science, Hacettepe University, Ankara 06800, Turkey.
² Department of Ophthalmology, Selcuk University Faculty of Medicine, Konya 42131, Turkey.
³ Department of Ophthalmology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey.

PMID: 24967185
PMCID: PMC4067653
DOI: 10.3980/j.issn.2222-3959.2014.03.07

Abstract

Aim: To investigate the association between apolipoprotein E (APOE) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG).

Methods: Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test.

Results: Although the frequency of APOE -219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (P=0.09). In glaucoma patients carrying GG genotype, mean linear C/D ratio was higher and progression was more compared to glaucoma patients with GT genotype.

Conclusion: APOE -219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation.

Keywords: apolipoprotein E; primary open angle glaucoma; promoter; single nucleotide polymorphism.