Neuromodulation in developing motor microcircuits

Curr Opin Neurobiol. 2014 Dec;29:73-81. doi: 10.1016/j.conb.2014.05.009. Epub 2014 Jun 24.

Abstract

Neuromodulation confers operational flexibility on motor network output and resulting behaviour. Furthermore, neuromodulators play crucial long-term roles in the assembly and maturational shaping of the same networks as they develop. Although previous studies have identified such modulator-dependent contributions to microcircuit ontogeny, some of the underlying mechanisms are only now being elucidated. Deciphering the role of neuromodulatory systems in motor network development has potentially important implications for post-lesional regenerative strategies in adults.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Efferent Pathways / physiology*
  • Humans
  • Motor Neurons / physiology*
  • Nerve Net / physiology*
  • Neurotransmitter Agents / physiology*

Substances

  • Neurotransmitter Agents