Flecainide and cardiac dysrhythmias during dental extraction under anaesthesia

Eur J Anaesthesiol. 1989 Jan;6(1):39-48.

Abstract

In a randomized double-blind study, either oral flecainide acetate 400 mg (a Class IC anti-dysrhythmic drug) or placebo was given in two divided doses 12 and 2 h pre-operatively to 38 patients undergoing outpatient molar extractions under halothane anaesthesia. The ECG was continuously monitored from the patients' arrival at the out-patient theatre until discharge, using a two-channel ambulatory magnetic tape recorder. There was a much lower incidence of ventricular dysrhythmias in patients who received flecainide (22%) than those who received placebo (75%) (P less than 0.05). In addition, dysrhythmias were both more severe and more prolonged in the untreated group, prompting treatment with intravenous practolol in seven patients (35%). Flecainide was well tolerated and no adverse effects were reported.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anesthesia, Dental* / adverse effects
  • Anesthesia, General* / adverse effects
  • Arrhythmias, Cardiac / chemically induced
  • Arrhythmias, Cardiac / prevention & control*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Flecainide / blood
  • Flecainide / therapeutic use*
  • Halothane* / adverse effects*
  • Humans
  • Middle Aged
  • Random Allocation
  • Tooth Extraction*

Substances

  • Flecainide
  • Halothane