Ventricular septal rupture complicating acute myocardial infarction: a contemporary review

Eur Heart J. 2014 Aug 14;35(31):2060-8. doi: 10.1093/eurheartj/ehu248. Epub 2014 Jun 26.


Ventricular septal rupture (VSR) after acute myocardial infarction is increasingly rare in the percutaneous coronary intervention era but mortality remains high. Prompt diagnosis is key and definitive surgery, though challenging and associated with high mortality, remains the treatment of choice. Alternatively, delaying surgery in stable patients may provide better results. Prolonged medical management is usually futile, but includes afterload reduction and intra-aortic balloon pump placement. Using full mechanical support to delay surgery is an attractive option, but data on success is limited to case reports. Finally, percutaneous VSR closure may be used as a temporizing measure to reduce shunt, or for patients in the sub-acute to chronic period whose comorbidities preclude surgical repair.

Keywords: Acute myocardial infarction; Percutaneous closure; VSR; Ventricular septal rupture.

Publication types

  • Review

MeSH terms

  • Combined Modality Therapy
  • Echocardiography
  • Humans
  • Myocardial Infarction / complications
  • Percutaneous Coronary Intervention / methods
  • Platelet Aggregation Inhibitors / therapeutic use
  • Risk Factors
  • Thoracic Surgical Procedures / methods
  • Time-to-Treatment
  • Ventricular Septal Rupture / etiology
  • Ventricular Septal Rupture / therapy*


  • Platelet Aggregation Inhibitors