In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1

K Arheden; M Rønne; N Mandahl; S Heim; K W Kinzler; B Vogelstein; F Mitelman

doi:10.1007/BF00288260

In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1

Hum Genet. 1989 Apr;82(1):1-2. doi: 10.1007/BF00288260.

Authors

K Arheden¹, M Rønne, N Mandahl, S Heim, K W Kinzler, B Vogelstein, F Mitelman

Affiliation

¹ Department of Clinical Genetics, University Hospital, Lund, Sweden.

PMID: 2497059
DOI: 10.1007/BF00288260

Abstract

Using in situ hybridization, we have localized the human putative oncogene GLI to chromosome subbands 12q13.3-14.1. The precise genomic site is of interest since the region 12q13-15 has been found to be consistently rearranged in neoplasia-associated chromosome abnormalities in lipomas, myxoid liposarcomas, uterine leiomyomas, and pleomorphic adenomas of the salivary gland.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Chromosome Banding*
Chromosomes, Human, Pair 12*
DNA, Neoplasm / genetics
DNA-Binding Proteins / genetics*
Humans
Metalloproteins / genetics*
Neoplasms / genetics
Nucleic Acid Hybridization
Oncogenes*
Translocation, Genetic

Substances

DNA, Neoplasm
DNA-Binding Proteins
Metalloproteins