A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication

Immunology. 1989 Apr;66(4):628-30.


Peripheral blood CD8+ T lymphocytes from human immunodeficiency virus (HIV)-infected individuals suppress replication of HIV in peripheral blood mononuclear cells (PBMC). This anti-viral activity appears to be mediated in part by a diffusible factor. Production of this lymphokine varies among infected individuals and may reflect the intrinsic ability of an individual's CD8+ cells to control HIV infection. In some cases in which factor activity is not apparent, contact of the CD8+ cells with infected CD4+ cells can produce for suppression of virus replication. These observations could lead to approaches for enhancing anti-viral responses in HIV-infected individuals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Differentiation, T-Lymphocyte / analysis
  • CD8 Antigens
  • Diffusion Chambers, Culture
  • HIV / physiology*
  • Humans
  • Lymphokines / physiology*
  • T-Lymphocytes / physiology*
  • Virus Replication*


  • Antigens, Differentiation, T-Lymphocyte
  • CD8 Antigens
  • Lymphokines