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. 2014 Jun 19;7:303-9.
doi: 10.2147/IJGM.S64812. eCollection 2014.

The Relationship Between Vitamin D Status and Idiopathic Lower-Extremity Deep Vein Thrombosis

Free PMC article

The Relationship Between Vitamin D Status and Idiopathic Lower-Extremity Deep Vein Thrombosis

Kamal Khademvatani et al. Int J Gen Med. .
Free PMC article


Background: Vitamin D has been shown to have an anticoagulant effect. A decrease in 25-hydroxyvitamin D [25(OH)D] concentration has also been associated with an increased risk of venous thromboembolism. Hence, we sought to determine the relationship between 25(OH) D levels and idiopathic lower-extremity deep vein thrombosis (DVT).

Methods: In a case control study, a total of 82 participants with idiopathic lower-extremity DVT were enrolled along with 85 sex- and age-matched healthy participants as controls. The plasma 25(OH)D levels were measured in all the studied samples.

Results: The participants' mean age was 47.1±12.3 years. Baseline characteristics were not significantly different between the groups. The concentration of 25(OH)D was significantly lower in the DVT group compared to that of the control group (17.9±10.3 versus 23.1±12.5 ng/mL, P=0.004). The prevalence of participants with deficient 25(OH)D levels was significantly higher in the both DVT and control groups than those with sufficient 25(OH)D levels (68.3% versus 13.4%, and 49.4% versus 28.2%, respectively, P=0.027). In a multivariate analysis, 25(OH)D levels and sex were found to be the only independent predictors of DVT (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.02-1.08, P=0.001 and OR 0.51, 95% CI 0.26-1.00, P=0.049, respectively).

Conclusion: Low levels of 25(OH)D are associated with idiopathic lower-extremity DVT. Further investigation is needed to establish determinants and probable causative role of 25(OH)D.

Keywords: idiopathic deep vein thrombosis; venous thromboembolism; vitamin D.


Figure 1
Figure 1
Study flow diagram. Abbreviations: DVT, deep vein thrombosis; VTE, venous thromboembolism.
Figure 2
Figure 2
Comparison of 25-hydroxyvitamin D [25(OH)D] levels between the deep vein thrombosis (DVT) and control groups.
Figure 3
Figure 3
Comparison of 25-hydroxyvitamin D [25(OH)D] levels between the subgroups by characteristics among deep vein thrombosis (DVT) participants. Abbreviations: DM, diabetes mellitus; HTN, hypertension; DLP, dyslipidemia.

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    1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–281. - PubMed
    1. Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117(4):503–511. - PMC - PubMed
    1. Lee JH, O’Keefe JH, Bell D, Hensrud DD, Holick MF. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol. 2008;52(24):1949–1956. - PubMed
    1. Pilz S, Dobnig H, Fischer JE, et al. Low vitamin D levels predict stroke in patients referred to coronary angiography. Stroke. 2008;39(9):2611–2613. - PubMed
    1. Kojima G, Bell C, Abbott RD, et al. Low dietary vitamin D predicts 34-year incident stroke: the Honolulu Heart Program. Stroke. 2012;43(8):2163–2167. - PMC - PubMed

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