Functional neuromodulation of chemosensation in vertebrates

Curr Opin Neurobiol. 2014 Dec;29:82-7. doi: 10.1016/j.conb.2014.05.010. Epub 2014 Jun 24.


Neuromodulation can be defined as a biophysical process that serves to modify-or modulate-the computation performed by a neuron or network as a function of task demands and behavioral state of the animal. These modulatory effects often involve substances extrinsic to the network under observation, such as acetylcholine (ACh), norepinephrine (NE), histamine, serotonin (5-HT), dopamine (DA), and a variety of neuropeptides. Olfactory and gustatory processes especially need to be adaptive and respond flexibly to changing environments, availability of resources and physiological needs. It is therefore crucial to understand the neuromodulatory processes that regulate the function of these systems.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gastrointestinal Tract / physiology*
  • Humans
  • Models, Neurological
  • Neurotransmitter Agents / metabolism
  • Neurotransmitter Agents / pharmacology
  • Neurotransmitter Agents / physiology*
  • Olfactory Pathways / physiology*
  • Sensory Receptor Cells / physiology*
  • Vertebrates


  • Neurotransmitter Agents