The chick embryo chorioallantoic membrane as a model for tumor biology

Exp Cell Res. 2014 Nov 1;328(2):314-24. doi: 10.1016/j.yexcr.2014.06.010. Epub 2014 Jun 24.


Among the in vivo models, the chick embryo chorioallantoic membrane (CAM) has been used to implant several tumor types as well as malignant cell lines to study their growth rate, angiogenic potential and metastatic capability. This review article is focused on the major compelling literature data on the use of the CAM to investigate tumor growth and the metastatic process.

Keywords: Angiogenesis; Chorioallantoic membrane; Metastasis; Tumor growth.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chick Embryo / pathology*
  • Chorioallantoic Membrane / pathology*
  • Humans
  • Neoplasm Metastasis / pathology
  • Neoplasms / pathology*
  • Neovascularization, Pathologic / pathology