Antifungal susceptibility profile of cryptic species of Aspergillus

Mycopathologia. 2014 Dec;178(5-6):427-33. doi: 10.1007/s11046-014-9775-z. Epub 2014 Jun 28.

Abstract

The use of molecular tools has led to the description of new cryptic species among different Aspergillus species complexes. Their frequency in the clinical setting has been reported to be between 10 and 15%. The susceptibility to azoles and amphotericin B of many of these species is low, and some of them, such as Aspergillus calidoustus or Aspergillus lentulus, are considered multi-resistant. The changing epidemiology, the frequency of cryptic species, and the different susceptibility profiles make antifungal susceptibility testing an important tool to identify the optimal antifungal agent to treat the infections caused by these species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amphotericin B / pharmacology*
  • Antifungal Agents / pharmacology*
  • Aspergillus / classification
  • Aspergillus / drug effects*
  • Aspergillus / genetics
  • Aspergillus / isolation & purification
  • Azoles / pharmacology*
  • Humans
  • Microbial Sensitivity Tests

Substances

  • Antifungal Agents
  • Azoles
  • Amphotericin B