Low signal intensity in U-fiber identified by susceptibility-weighted imaging in two cases of progressive multifocal leukoencephalopathy

J Neurol Sci. 2014 Sep 15;344(1-2):198-202. doi: 10.1016/j.jns.2014.06.018. Epub 2014 Jun 19.


Magnetic resonance imaging (MRI) is a useful tool for diagnosing and monitoring progressive multifocal leukoencephalopathy (PML). Although characteristic MRI findings of PML are well known, we noted a potential new finding for this disease on susceptibility-weighted imaging (SWI). Two patients with PML were studied and followed using MRI. SWI revealed low signal intensities in U-fibers adjacent to the white matter lesions of PML. These findings progressed along with the disease progression. The cause underlying these findings remains unclear. This new finding suggests that SWI is useful for the diagnosis of PML. It can provide a helpful clue in a clinical setting.

Keywords: MRI; Progressive multifocal leukoencephalopathy; Susceptibility-weighted imaging; U-fiber.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diffusion Magnetic Resonance Imaging
  • Disease Susceptibility / pathology*
  • Female
  • Follow-Up Studies
  • HIV Infections / complications
  • Humans
  • Kidney Failure, Chronic / complications
  • Leukoencephalopathy, Progressive Multifocal / etiology
  • Leukoencephalopathy, Progressive Multifocal / pathology*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neurologic Examination
  • White Matter / pathology