A defect in mitochondrial electron-transport activity (NADH-coenzyme Q oxidoreductase) in Leber's hereditary optic neuropathy

N Engl J Med. 1989 May 18;320(20):1331-3. doi: 10.1056/NEJM198905183202007.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Electron Transport
  • Hereditary Sensory and Motor Neuropathy / enzymology*
  • Humans
  • Male
  • Mitochondria / enzymology*
  • Mitochondria / metabolism
  • NAD(P)H Dehydrogenase (Quinone)
  • Optic Atrophies, Hereditary / enzymology*
  • Optic Atrophies, Hereditary / genetics
  • Quinone Reductases / deficiency*
  • Quinone Reductases / genetics
  • Rotenone / metabolism

Substances

  • Rotenone
  • NAD(P)H Dehydrogenase (Quinone)
  • Quinone Reductases