Supercooling enables long-term transplantation survival following 4 days of liver preservation

Nat Med. 2014 Jul;20(7):790-3. doi: 10.1038/nm.3588. Epub 2014 Jun 29.


The realization of long-term human organ preservation will have groundbreaking effects on the current practice of transplantation. Herein we present a new technique based on subzero nonfreezing preservation and extracorporeal machine perfusion that allows transplantation of rat livers preserved for up to four days, thereby tripling the viable preservation duration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cold Temperature*
  • Liver Transplantation*
  • Organ Preservation*
  • Rats
  • Survival Rate*