Double-blind evaluation of the effect of acute amantadine on cocaine craving

Psychopharmacology (Berl). 1989;97(3):402-3. doi: 10.1007/BF00439458.


Single doses of amantadine hydrochloride and placebo were administered in a double-blind cross-over design on separate days to ten actively craving cocaine abusers in treatment. Pharmacological treatment did influence cocaine craving, but amantadine was less effective than placebo.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amantadine / therapeutic use*
  • Cocaine / pharmacology*
  • Double-Blind Method
  • Humans
  • Substance-Related Disorders / drug therapy*
  • Substance-Related Disorders / psychology


  • Amantadine
  • Cocaine