Copper mediated neurological disorder: visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease

J Trace Elem Med Biol. 2015 Jan;29:11-23. doi: 10.1016/j.jtemb.2014.05.003. Epub 2014 Jun 2.

Abstract

Copper (Cu) is a vital redox dynamic metal that is possibly poisonous in superfluous. Metals can traditionally or intricately cause propagation in reactive oxygen species (ROS) accretion in cells and this may effect in programmed cell death. Accumulation of Cu causes necrosis that looks to be facilitated by DNA damage, followed by activation of P53. Cu dyshomeostasis has also been concerned in neurodegenerative disorders such as Alzheimer, Amyotrophic lateral sclerosis (ALS) or Menkes disease and is directly related to neurodegenerative syndrome that usually produces senile dementia. These mortal syndromes are closely related with an immense damage of neurons and synaptic failure in the brain. This review focuses on copper mediated neurological disorders with insights into amyotrophic lateral sclerosis, Alzheimer and Menkes disease.

Keywords: Alzheimer disease; Amyotrophic lateral sclerosis; Copper; Menkes disease; Neurological disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / etiology*
  • Alzheimer Disease / pathology
  • Amyotrophic Lateral Sclerosis / etiology*
  • Amyotrophic Lateral Sclerosis / pathology
  • Brain / metabolism
  • Brain / pathology
  • Copper / adverse effects*
  • Humans
  • Menkes Kinky Hair Syndrome / etiology*
  • Menkes Kinky Hair Syndrome / pathology
  • Oxidative Stress

Substances

  • Copper